Models – Music Massage http://music-massage.com/ Sat, 12 Jun 2021 00:47:06 +0000 en-US hourly 1 https://wordpress.org/?v=5.7.2 https://music-massage.com/wp-content/uploads/2021/03/cropped-musicemassage-32x32.png Models – Music Massage http://music-massage.com/ 32 32 Local engineer uses Loveland Makerspace library to build model SpaceX rocket – Loveland Reporter-Herald https://music-massage.com/local-engineer-uses-loveland-makerspace-library-to-build-model-spacex-rocket-loveland-reporter-herald/ https://music-massage.com/local-engineer-uses-loveland-makerspace-library-to-build-model-spacex-rocket-loveland-reporter-herald/#respond Fri, 11 Jun 2021 23:45:51 +0000 https://music-massage.com/local-engineer-uses-loveland-makerspace-library-to-build-model-spacex-rocket-loveland-reporter-herald/ A local engineer took full advantage of Loveland Public Library’s Makerspace to take his love for rockets to the next level, building an almost 6-foot-tall replica of the SpaceX Falcon 9 rocket. Greg Caster, a sales engineer at Otterbox, said he recalled building model rockets with his father as a child. Several years ago, he […]]]>

A local engineer took full advantage of Loveland Public Library’s Makerspace to take his love for rockets to the next level, building an almost 6-foot-tall replica of the SpaceX Falcon 9 rocket.

Greg Caster, a sales engineer at Otterbox, said he recalled building model rockets with his father as a child. Several years ago, he attended a rocket launch sponsored by the Northern Colorado Rocketry Club, an event that made him fully love rockets.

“I had no idea the hobby evolved so much beyond rockets (models) that a lot of us used as kids,” he said. “Once I realized you could make big rockets and send them high in the air, I got hooked. “

Caster said during the pandemic he began to dive into rockets and rockets as a hobby. He said he spent a lot of time reading about rockets and making his own rocket models.

He said much of his inspiration for building the 6-foot, 14-pound model he made was watching the SpaceX Falcon 9 spaceflight launch demo 2, which carried NASA astronauts to the International Space Station last May.

LOVELAND, CO: A photo of Greg Caster’s SpaceX Falcon 9 rocket he built at the Loveland Public Library. (Photo courtesy of Loveland Public Library)

“I was caught up,” he says. “I was watching in real time, I blocked time on my work schedule.”

“I was like ‘I’m going to make this rocket,'” he added.

From there, Caster set to work building his model. He said after browsing the internet he was able to find downloaded 3D printable designs based on the exact rocket he saw flying into space.

However, to build the rocket he considers the most complex model he has ever created, Caster said he needed some serious 3D printing equipment; something the Loveland Public Library has been able to accommodate with its Makerspace.

The space offers a multitude of technologies, programs and equipment for anyone who wants to learn more and use them.

“It is extremely accessible to both access and use at a cost (from a point of view),” Caster said. “For many people, owning a 3D printer is prohibitive. You don’t need to own (yours), you can go to the Loveland Library and use theirs.

“By having these machines here, community members can use them for free,” said Erik Rock, deputy director of technology services at the Loveland Public Library. “The other benefit of being at the library is that people can get help. “

Rock said the library’s suite of machines, such as multiple 3D printers, a die-cutter, and more, are being offered to the community for only the small price of printing supplies. He said if somebody wants to print something big, he can send a drawing to the library and he can start the printer.

Caster said this space and equipment were instrumental in building his model, and he implored the community to use it.

“Whatever you have to cook in your brain, they can help you bring it to life,” he said.

Rock said the space also offers manufacturers and creators the opportunity to experiment and learn about the machines available, as well as to grow as creators.

“Think of it as a trip,” he said. “To do what you want to do you will need practice. But that’s the spirit of the maker movement, that’s the only reason you do something instead of buying it.

Rock said he was excited when Caster started sending out his model designs for printing.

“Anytime we have a multi-room or giant project that customers come to, I’m very excited,” he said. “I love to push our equipment to its limits.

Caster was ready to fly his model, a 1 / 36th model of the original rocket, by the time another flying day arrived. He brought his rocket to Pawnee National Grassland on June 4 and said with family, friends and colleagues around him that he was all nervous.

PAWNEE NATIONAL GRASSLAND – June 4, 2021: Greg and Tina Caster pose with Greg’s SpaceX Falcon 9 rocket model at the Pawnee Grasslands before launch. Greg Caster said the rocket model was around 6 feet tall and around 14 pounds. (Photo courtesy of Greg Caster)

“I was shaking, my hands were literally shaking when I connected the electrical connection,” he said. “I walked away and focused everyone with their cameras and just sat there and watched it roar straight into space.”

The rocket reached a total of 6,102 feet.

“It was an incredible relief,” Caster said. “The nerves, the excitement and then this relief, this accomplishment. I still get goosebumps thinking about it.

Caster said that anyone like him, young or old, who is interested in rockets should research the craft by starting small; he said visiting the local hobby store can put someone on their way to space.

“They have everything you need to get started in the rocket world,” he said.

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Blueground presents the Nomads flexible working model https://music-massage.com/blueground-presents-the-nomads-flexible-working-model/ https://music-massage.com/blueground-presents-the-nomads-flexible-working-model/#respond Fri, 11 Jun 2021 08:00:45 +0000 https://music-massage.com/blueground-presents-the-nomads-flexible-working-model/ Greece: Proptech’s Blueground startup introduced Blueground Nomads, a flexible and innovative working model designed to empower the employee. True to its vision of making people feel “at home” wherever they choose to live, Blueground now offers its employees the opportunity to feel “at home” wherever they choose to work. Listening to new trends in teleworking […]]]>

Greece: Proptech’s Blueground startup introduced Blueground Nomads, a flexible and innovative working model designed to empower the employee.

True to its vision of making people feel “at home” wherever they choose to live, Blueground now offers its employees the opportunity to feel “at home” wherever they choose to work.

Listening to new trends in teleworking models around the world [flexible / hybrid] and aiming to provide a working environment to international standards and lead the way, Blueground aims to redefine the concept of ‘work from home’.

To give employees even more flexibility, Blueground Nomads includes three different flexible working models, designed to be able to help them choose the ideal working conditions for the needs of each role and for them personally. At the same time, for those who choose to work in one of the 14 cities in which the company is established, Blueground Nomads offers a discount on its apartments, to help them adapt even more easily to their new position.

Specifically, the three flexible working models of Blueground Nomads:

  • “Work from Anywhere”: Blueground employees can customize their schedule to suit their personal needs and preferences, according to the needs of their roles. Choices range from working five days a week at one of Blueground’s offices around the world, to full telecommuting and a mid-size hybrid model. [one to four days a week in the office]. However, employees can work from anywhere, if they choose to live and work in any of the global markets in which Blueground operates, and they can also benefit from special rates for Blueground apartment rentals. [all employees already receive two weeks of free accommodation in a Blueground apartment each year].

  • “Short or Long Term Assignment”: Blueground believes that living and working in a new location benefits mind and spirit, which is why it urges its employees to volunteer for short or long term assignments. long term around the world, with the ultimate goal of their personal and professional development. The duration of the missions depends on the resulting projects and varies from two months to one year.

  • “International transfer”: the third pillar of Blueground’s new initiative is international transfer. Blueground employees can pursue a career in one of the company’s subsidiaries in another country. As these are permanent transfers, an internal recruitment process is followed to manage them.

Blueground Co-Founder and CEO Alex Chatzieleftheriou said: “Flexibility, exploration and the freedom to choose how and where to live your life is at the heart of Blueground’s business model. Having lived in 15 cities around the world, I believe exposure to different geographies and cultures broadens personal horizons and helps people evolve.

“Through the Blueground Nomads program, we remove barriers and provide our employees with options, opportunities and tools to choose the best work environment for them,” he added.

By implementing the new initiative, Blueground aims to develop new talents who have the opportunity to unleash their creativity and skills, enjoy the flexibility of work and develop as professionals and personalities.

Founded in Athens in 2013, Blueground has rapidly grown in the field of proptech and is present in Greece, the United States, Great Britain, France, Austria, the United Arab Emirates and Turkey. The startup also won a Shortyz Award 2021 for the prize for “Best urban property management company”.

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Can a subscription model fix primary care in the United States? https://music-massage.com/can-a-subscription-model-fix-primary-care-in-the-united-states/ https://music-massage.com/can-a-subscription-model-fix-primary-care-in-the-united-states/#respond Thu, 10 Jun 2021 10:57:00 +0000 https://music-massage.com/can-a-subscription-model-fix-primary-care-in-the-united-states/ In April, San Francisco-based primary care company One Medical revealed a mind-boggling compensation package for its chief executive and chairman, Amir Dan Rubin. His $ 199 million salary, particularly notable at a company that has yet to turn a profit, made Rubin the second highest-paid CEO in the United States last year, but only on […]]]>

In April, San Francisco-based primary care company One Medical revealed a mind-boggling compensation package for its chief executive and chairman, Amir Dan Rubin. His $ 199 million salary, particularly notable at a company that has yet to turn a profit, made Rubin the second highest-paid CEO in the United States last year, but only on paper.

About $ 197.5 million of his salary is in stock options. For Rubin to get all that money, One Medical’s stock, listed as 1Life Healthcare, must rise sharply over the next seven years, almost tripling its current price.

In short, his pay is less of a quick jackpot than a general statement of One Medical’s ambitious vision to make primary care more accessible, technologically compatible and patient-friendly, while reducing healthcare costs for employers and individuals.

Many other companies, ranging from small start-ups to larger, more established businesses, are selling similar new and improved primary care concepts.

Some offer it directly to individuals; others target Medicare registrants. Perhaps the most promising clients are employers, who insure around 157 million American workers and their dependents, and have long been frustrated by uneven primary care and ever-increasing health costs.

“Direct” primary care companies, as they are often referred to, face stiff competition from each other as well as from large regional health systems and their affiliated physician groups, which still dominate the field.

Analysts say these emerging primary care companies have significant room for growth due to growing frustration with the medical status quo and because they currently only hold a tiny share of the US $ 260 billion primary care market. of dollars.

“I think that ultimately they are going to become more and more accepted, rack up patients and attract clinicians who want to provide a different level of care,” said Richard Close, general manager of equity research. in health at Canaccord Genuity in Nashville, Tennessee. But he added that “all these companies combined could grow very significantly and only hamper the overall system.”

Emergency care centers and walk-in clinics at retailers like Target and pharmacies like CVS, in addition to telehealth companies like Teladoc and Doctors on Demand, are also vying for a share of the primary care market. .

As a reminder of the competitive challenges ahead, the stock prices of One Medical and Teladoc fell in mid-March after Amazon announced plans to start offering its telehealth and home visiting service as a benefit. to employees nationwide.

“Amazon is a threat because Amazon knows how to appeal to consumers,” said Gary Kurtzman, lecturer at the Wharton Business School and CEO of Prostasia Health, a healthcare technology investment consultancy.

The attractiveness of these companies has grown as employers increasingly seek to address a shortage of high-quality primary care and reduce spending on the health of their workforce, said Ellen. Kelsay, CEO and President of the Business Group on Health, which represents large employers.

Studies show a strong correlation between access to primary care and lower spending on expensive medical services such as emergency room visits, surgeries and hospitalizations. Yet in the United States, primary care accounts for only about 5-7% of total health spending, compared to 14% in the 36 member countries of the Organization for Economic Co-operation and Development.

The big bet for One Medical and similar companies is that an increase in spending on primary care will increase their bottom line while lowering the overall healthcare costs of their clients.

A study published last year in the JAMA Network Open showed that employees of SpaceX, based in Hawthorne, Calif., Who received most of their primary care at One Medical’s on-site health clinic were generating 109% more in spending on primary care but 45% less on health care. overall than those who used One Medical little or not at all.

These direct primary care companies typically offer a digital platform as their first point of contact, which allows members to make appointments and chat via text, email or video 24/7 with their medical providers. .

They have combined this technology with physical clinics staffed with doctors, nurse practitioners and medical staff, where members can go for exams, prescription drugs, lab tests, scans, vaccinations, sessions. physiotherapy and mental health visits. Patients generally spend more time with their providers than in a traditional doctor’s office.

One Medical’s goal is to improve healthcare for “multiple stakeholders simultaneously,” Rubin said in a recent interview with KHN. “How to delight consumers, serve employers and payers? How to make medicine the best environment for providers? “

Part of the company’s response is to pay physicians instead of paying fees for each visit. This takes the pressure off of booking many visits, which Rubin says helps doctors spend more time with each patient.

One Medical will offer its combination of telehealth and in-person visits to 22 metropolitan areas across the United States within about a year, up from nine in 2020, Rubin said. It had nearly 600,000 members at the end of March, up 31% from the previous year. When One Medical started in 2007, it only sold individual memberships, for which it currently charges $ 199 per year. But since then, it has more and more established itself in the employer market. For the record, his patients are satisfied with the care they receive.

“One Medical says your appointment is at 10 am and my nurse practitioner comes out at 10 am to pick me up,” said Kathleen Wiegand, 63, a member of One Medical in Washington, DC. to wait for a meeting. “

Premise Health, based in Brentwood, Tennessee, is the largest player in the employer segment of the direct care market, with over $ 1 billion in annual revenue, 11 million employer-sponsored members through 1,600 large companies and municipal employers and around 850 health centers. Most of these centers are located on the sites of its corporate and local government customers.

“Our bet for the future is that it is the combination of digital and physical access that will generate lasting value and a better experience for the member, rather than pure digital or pure physical,” said Jami Doucette, president of Premise.

Doucette said his company provides an entry point to medicine that is “an alternative to hospital-owned primary care physicians who are dragged down by the volume of expensive procedures.”

Eden Health, a New York-based start-up, provides a similar service to small and medium-sized businesses, and also contracts directly with commercial real estate companies who wish to provide on-site medical facilities to businesses that are their tenants.

As the pandemic eases and many workers return to the office with safety in mind, providing on-site medical care can help business owners raise rents, said Matt McCambridge, co-founder and CEO of Eden Health, 29 years. “What the owners are trying to do is create a set of amenities that allows them to be a premium Class A location, and health is really a key part of that,” he said. .

The San Francisco-based start-up Forward Health, meanwhile, markets itself exclusively to individuals. It charges a flat monthly fee of $ 149 for access to digital health, in-person visits, and technology that the company says can check for signs of skin cancer, perform genetic testing and return results. complete blood tests in 12 minutes.

While positioning themselves as “disruptors” in an industry that prioritizes volume of health services, many direct care companies nonetheless participate in their members’ health plan networks, and some receive fee-for-service payments. these diets.

One Medical, for example, derives about 37% of its revenue from these payments.

“It’s just the way the American health care system is organized. If you want to serve people easily, you say, ‘Hey, I take your assurance. And if you want to easily serve employers, you say, “I’m part of your network,” Rubin said.

“But what is powerful is that without changing the way the system pays, we can still reduce the cost of care,” he added. “We don’t have to wait for a mythical unicorn from a reimbursement system to get these kinds of results.”

This story was produced by KHN, which publishes California Healthline, an independent editorial service of the California Health Care Foundation.

This article was reprinted from khn.org with permission from the Henry J. Kaiser Family Foundation. Kaiser Health News, an editorial independent news service, is a program of the Kaiser Family Foundation, a non-partisan health policy research organization not affiliated with Kaiser Permanente.

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Climate models can predict decadal variations in rainfall on the Tibetan plateau https://music-massage.com/climate-models-can-predict-decadal-variations-in-rainfall-on-the-tibetan-plateau/ https://music-massage.com/climate-models-can-predict-decadal-variations-in-rainfall-on-the-tibetan-plateau/#respond Wed, 09 Jun 2021 18:02:34 +0000 https://music-massage.com/climate-models-can-predict-decadal-variations-in-rainfall-on-the-tibetan-plateau/ Summer precipitation on the Tibetan Plateau is highly predictable over multi-year timescales in large ensemble forecasts, according to a research team led by ZHOU Tianjun of the Institute of Atmospheric Physics (IAP) of the Chinese Academy of Sciences. The study, published in Scientists progress June 9, shows that the predictable summer rainfall signal in the […]]]>

Summer precipitation on the Tibetan Plateau is highly predictable over multi-year timescales in large ensemble forecasts, according to a research team led by ZHOU Tianjun of the Institute of Atmospheric Physics (IAP) of the Chinese Academy of Sciences.

The study, published in Scientists progress June 9, shows that the predictable summer rainfall signal in the Tibetan Plateau hinterland is significantly underestimated in advanced decadal forecast models.

The predictable signal is so weak that it can be masked by unpredictable noise. “The predictably weak signal is due to the low signal-to-noise ratios in the models compared to the real world,” said ZHOU, corresponding author of the study. “This phenomenon is kind of a deficiency in climate models, but it also prompts us to once again recognize the decadal predictability of forecast models.”

ZHOU is Principal Investigator at the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics at IAP. He is also a professor at the University of the Chinese Academy of Sciences.

ZHOU and his team used large assemblies from the Sixth Coupled Model Intercomparison Project (CMIP6) of the Decadal Climate Prediction Project (DCPP), an archive of comprehensive decadal prediction experiments based on various climate models, to eliminate stochastic noise. unpredictable and extract the predictable signal. summer rainfall in the Tibetan plateau.

The researchers produced realistic forecasts using a variance adjustment post-processing procedure, indicating that summer precipitation on the Tibetan Plateau is highly predictable over ten-year time scales.

The Tibetan Plateau has the most glaciers outside of the Arctic and Antarctic. Melt water supplies more than 10 major rivers, including the Yangtze River, the Yellow River and the Ganges. “Our results mean a lot for the management of water resources for about 40% of the world’s population,” ZHOU said.

Based on real-time forecasts, the researchers revealed that the Tibetan Plateau hinterland will become wetter, with a 12.8% increase in rainfall for the period 2020-2027 compared to 1986-2005.

“The government and scientists have recognized the urgent need for effective short-term climate information (2021-2040), but there are great uncertainties in traditional short-term climate projections based on summer rainfall scenarios on the Tibetan Plateau. due to internal variability. in the climate system, ”ZHOU said. “Our results demonstrate that decadal climate prediction systems can be a valuable tool in overcoming the shortcoming of traditional projection uncertainties based on short-term climate change scenarios on the Tibetan Plateau.”

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New atomic-level model helps explain how SARS-CoV-2 causes significant lung damage https://music-massage.com/new-atomic-level-model-helps-explain-how-sars-cov-2-causes-significant-lung-damage/ https://music-massage.com/new-atomic-level-model-helps-explain-how-sars-cov-2-causes-significant-lung-damage/#respond Wed, 09 Jun 2021 02:13:00 +0000 https://music-massage.com/new-atomic-level-model-helps-explain-how-sars-cov-2-causes-significant-lung-damage/ Scientists at the US Department of Energy’s (DOE) Brookhaven National Laboratory have published the first detailed atomic-level model of the SARS-CoV-2 ‘envelope’ protein bound to a human protein essential for maintaining the lining of lungs. The model showing how the two proteins interact, which was just published in the journal Nature Communications, helps explain how […]]]>

Scientists at the US Department of Energy’s (DOE) Brookhaven National Laboratory have published the first detailed atomic-level model of the SARS-CoV-2 ‘envelope’ protein bound to a human protein essential for maintaining the lining of lungs. The model showing how the two proteins interact, which was just published in the journal Nature Communications, helps explain how the virus could cause significant lung damage and escape from the lungs to infect other organs in COVID patients. 19 particularly vulnerable. The results may speed up the search for drugs to block the more serious effects of the disease.

“By getting atomic-level details of protein interactions, we can explain why damage occurs and look for inhibitors that can specifically block these interactions,” said lead author of the study, Qun Liu, structural biologist at Brookhaven. Lab. “If we can find inhibitors, the virus will not do as much damage. It could give people with compromised health a much better chance for their immune systems to successfully fight the virus.”

Scientists discovered the details and developed the molecular model using one of the new cryoelectron microscopes from Brookhaven Lab’s Laboratory for Biomolecular Structure (LBMS [https://www.bnl.gov/cryo-EM/]), a new research facility built with New York State funding adjacent to the Brookhaven National Synchrotron II Light Source (NSLS-II [https://www.bnl.gov/nsls2/about-NSLS-II.php]).

“LBMS opened last summer [https://www.bnl.gov/newsroom/news.php?a=117344] ahead of schedule due to its importance in the battle against COVID-19, ”said Sean McSweeney, director of LBMS and co-author of the article. “LBMS and NSLS-II offer complementary protein imaging techniques and both play an important role in deciphering the details of the proteins involved in COVID-19. This is the first article published based on the results of the new installation. “

Liguo Wang, director of scientific operations at LBMS and another co-author of the article, explained that “cryoelectron microscopy (cryo-EM) is particularly useful for studying membrane proteins and dynamic protein complexes, which can be difficult to crystallize for. protein crystallography, another common technique for studying protein structures. With this technique, we created a 3D map from which we could see how the individual protein components fit together. “

“Without cryo-EM, we would not have been able to obtain a structure to capture the dynamic interactions between these proteins,” said Liu.

Triggering of a pulmonary disturbance

The SARS-CoV-2 (E) envelope protein, which is found on the outer membrane of the virus alongside the now famous coronavirus spike protein, helps assemble new viral particles inside infected cells . Studies published at the start of the COVID-19 pandemic have shown that it also plays a crucial role in the diversion of human proteins to facilitate the release and transmission of the virus. Scientists hypothesize that it does so by binding to human cell junction proteins, taking them away from their usual job of keeping the junctions between lung cells tightly sealed.

“This interaction can be good for the virus, and very bad for humans, especially elderly patients with COVID-19 and those with pre-existing health issues,” Liu said.

When lung cell junctions are disrupted, immune cells step in to try to repair the damage, releasing small proteins called cytokines. This immune response can make matters worse by triggering massive inflammation, causing a “cytokine storm” and subsequent acute respiratory distress syndrome.

Additionally, because the damage weakens cell-cell connections, viruses may escape the lungs more easily and pass through the bloodstream to infect other organs, including the liver, kidneys, and blood vessels.

“In this scenario, most of the damage would occur in patients with more virus and more E protein produced,” Liu said. And it could turn into a vicious cycle: more viruses producing more E proteins and more cell junction proteins are extracted, causing more damage, more transmission and more viruses again. Additionally, any existing damage, such as scarring of lung cells, would likely make it more difficult for COVID patients to recover from the damage.

“That’s why we wanted to study this interaction – to understand the details at the atomic level of how E interacts with one of these human proteins to learn how to interrupt the interactions and reduce or block these serious effects,” Liu said. .

From stains to drips from card to model

Scientists obtained atomic-level details of the interaction between E and a human cell-lung junction protein called PALS1 by mixing the two proteins together, freezing the sample quickly, and then studying the frozen sample with the cryo -EM. Electron microscopes use high energy electrons to interact with the sample in the same way that ordinary optical microscopes use beams of light. But electrons allow scientists to see things on a much smaller scale due to their extremely short wavelength (100,000 times shorter than that of visible light).

The first images looked like nothing more than spots. But image processing techniques allowed the team to select spots that were true complexes of the two proteins.

“We used a two-dimensional average and started to see some structural features shared between these particles. Our images showed the complex in different orientations but at a fairly low resolution,” Liu said. “Then we use computational tools and computational infrastructure at Brookhaven’s Computational Science Initiative [https://www.bnl.gov/compsci/] to perform three-dimensional reconstructions. These give us a 3D model – an experimental map of the structure. “

With an overall resolution of 3.65 Angstroms (the size of just a few atoms), the map contained enough information about the unique characteristics of the individual amino acids that make up the two proteins for scientists to integrate the known structures of these amino acids. in the map.

“We can see how the chain of amino acids that makes up the PALS1 protein folds up to form three structural components, or domains, and how the much smaller chain of amino acids that makes up protein E fits into a hydrophobic pocket. between two of these areas, ”Liu said.

The model provides both the structural details and an understanding of the intermolecular forces that allow E proteins deep within an infected cell to snatch PALS1 from its place at the outer edge of the cell.

“Now we can explain how the interactions pull PALS1 from the junction of human lung cells and contribute to damage,” Liu said.

Implications for drugs and evolution

“This structure provides the basis for our colleagues in computer science to run docking studies and molecular dynamics simulations to search for drugs or drug-like molecules that could block the interaction,” said John Shanklin, president from the Department of Biology at Brookhaven Lab. [https://www.bnl.gov/biosciences/] and a co-author on paper. “And if they identify promising leads, we have the analytical capabilities to quickly screen these drug candidates to identify those that could be essential in preventing the severe consequences of COVID-19. “

Understanding the dynamics of this protein interaction will also help scientists track the evolution of viruses like SARS-CoV-2.

“When the viral protein pulls PALS1 out of the cell junction, it could help the virus to spread more easily. This would provide a selective advantage for the virus. Any traits that increase the survival, spread or release of the virus are likely to ‘be restrained,’ Liu said.

The more the virus continues to circulate, the more likely it is that new evolutionary benefits will emerge.

“This is one more reason why it is so essential for us to identify and implement promising therapies,” Liu said. “In addition to preventing the most serious infections, drugs that effectively treat COVID-19 will keep us ahead of these mutations. “

Source:

Brookhaven National Laboratory

Journal reference:

Chai, J., et al. (2021) Structural basis for the recognition of the SARS-CoV-2 envelope protein from the human cell junction protein PALS1. Natural communications. doi.org/10.1038/s41467-021-23533-x.

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New generative model has broad implications in developmental biology and regenerative medicine https://music-massage.com/new-generative-model-has-broad-implications-in-developmental-biology-and-regenerative-medicine/ https://music-massage.com/new-generative-model-has-broad-implications-in-developmental-biology-and-regenerative-medicine/#respond Tue, 08 Jun 2021 05:04:00 +0000 https://music-massage.com/new-generative-model-has-broad-implications-in-developmental-biology-and-regenerative-medicine/ Various forms of complex multicellular organisms have evolved on Earth, ranging from the simple Volvox carterii which has only 2 cell types to us humans with over 200 cell types. All originate from a single-celled zygote and their developmental processes depend on the regulation of switch-type genes. These processes have been studied in detail in […]]]>

Various forms of complex multicellular organisms have evolved on Earth, ranging from the simple Volvox carterii which has only 2 cell types to us humans with over 200 cell types. All originate from a single-celled zygote and their developmental processes depend on the regulation of switch-type genes.

These processes have been studied in detail in a few model organisms such as the worm C. elegans, and the fruit fly D. melanogaster. It is also known that the key molecules and mechanisms involved in the development of multicellular organisms are highly conserved across species.

What is also remarkable is that only a handful of molecules and mechanisms that go into the development of a multicellular organism can generate such a diversity of shapes and complexity. Recently, researchers at the Center for Soft and Living Matter at the Institute for Basic Science investigated how this is possible using a simple mathematical model.

Through this work, they sought to answer two seemingly opposing questions: what are the limits of diversity that can be generated by development, and what common characteristics are shared among all multicellular organisms during their development.

Three processes are common to the biological development of all multicellular organisms: cell division, cell signaling and gene regulation. As such, the model in this study generated millions of these rules and explored them impartially.

The maps generated by the model represent how one type of cell transforms into another during the life of the organism. Traditionally, old cell-type maps based on single-celled transcriptomics are biased to resemble a tree, with stem cells located at the root of the tree and increasingly specialized cells appearing downstream along the branches of the tree. ‘tree.

However, the cell-type maps produced by the new mathematical model were far from tree-like; it was found that there were many cross-links between different branches of cell types. These resulted in directed acyclic charts, and tree lines were found to be the least common. This means that it is possible that several developmental pathways converge to the terminal cell type in the maps generated by the model.

Surprisingly, it was also found that many organisms produced by the mathematical model were endowed with the ability to regenerate lost cells, without any selection imposed by the authors. When a single cell type is isolated from the adult organism, a single cell can transform and reconstitute all the other cell types.

This ability to generate all the cells in the body is called pluripotency, and these cells endow the model organisms with the regenerative capacity of the whole body. Interestingly, most tree lines contained few pluripotent cells, compared to other types of graphs.

While mammals, including humans, are particularly bad at regenerating damaged parts, many animals such as worms and hydras are exceptionally good at this ability. In fact, whole body regeneration occurs largely in the multicellular animal tree of life, and therefore, it has been hypothesized that whole body regeneration could be an epiphenomenon of biological development itself.

The fact that pluripotency has occurred in this much simplified model suggests that this trait is indeed likely to emerge due to the development process itself, and no special additional components are required to set it up.

In addition to these results, it is expected that the framework of this model can be used to study many other aspects of development. This generative model is simple and modular, and it can be easily extended to explore important processes that were not included in the present study, such as the effect of the spatial arrangement of cells and the effect of cell death. .

The researchers further described some possible real-life experiments to test some of the predictions made by their mathematical model. It is hoped that the framework of this model will prove useful in discovering new features of development, which may have a wide range of implications in developmental biology and regenerative medicine.

Source:

Institute of Basic Sciences

Journal reference:

Mani, S & Tlusty, T., (2021) Comprehensive study of development programs reveals paucity of tree lineage graphics and ubiquitous regeneration. BMC Biology. doi.org/10.1186/s12915-021-01013-4.

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Algorithm provides precise segmentation of pancreas on CT https://music-massage.com/algorithm-provides-precise-segmentation-of-pancreas-on-ct/ https://music-massage.com/algorithm-provides-precise-segmentation-of-pancreas-on-ct/#respond Mon, 07 Jun 2021 07:05:00 +0000 https://music-massage.com/algorithm-provides-precise-segmentation-of-pancreas-on-ct/ A team of researchers from the Mayo Clinic in Rochester, MN, have trained a model that produces very precise segmentations of the pancreas. Importantly, the algorithm worked equally well on normal cases as it did on pancreatic ductal adenocarcinoma, according to presenter Panagiotis Korfiatis, PhD, The pancreatic volume estimated on a CT scan can be […]]]>

A team of researchers from the Mayo Clinic in Rochester, MN, have trained a model that produces very precise segmentations of the pancreas. Importantly, the algorithm worked equally well on normal cases as it did on pancreatic ductal adenocarcinoma, according to presenter Panagiotis Korfiatis, PhD,

The pancreatic volume estimated on a CT scan can be used as a biomarker to assess a number of diseases, including diabetes. In addition, segmentation of the pancreas is required for artificial intelligence (AI) -based cancer detection models. Unfortunately, manual segmentation of the pancreas is time consuming and cumbersome, and intra- and inter-sector variability is unknown, the researchers said.

For AI models to be used in the clinic, the process must be automated to provide a fast and scalable implementation independent of variations between users, Korfiatis said. However, segmentation of the pancreas is a difficult task.

“The pancreas is a small organ with considerable variability and complexity in anatomy, location, shape and attenuation,” he said. “Additionally, the tumor may be isodense with the pancreas or peripancreatic tissue, further increasing the difficulty of segmenting the … pancreas.”

As part of an effort to develop software for early detection of pancreatic cancer, the researchers sought to use a 3D convolutional neural network to automatically segment the pancreas. Their deep learning algorithm works in two phases. After first placing a bounding box around the pancreas on the CT image, the model then segments the pancreas and places the segmentation in the original CT dataset.

The researchers trained, validated and tested their algorithm on an internal dataset of 2,639 abdominal CT scans acquired during the portal phase between 2006 and 2017. These exams were acquired on scanners from several vendors at a thickness of slice 5 mm.

The CT studies included 519 cases of pancreatic ductal adenocarcinoma. Of these, 1,612 were used for training and 284 were used for validation. The algorithm was then tested on the remaining 473 exams, which included 110 cases of pancreatic ductal adenocarcinoma.

After internal testing, the authors then tested the algorithm on two external datasets: the Medical Segmentation Decathlon dataset (102 cases of pancreatic ductal adenocarcinoma) and the National Institutes of Pancreas-CT dataset. Health (NIH) from the United States (80 normal cases). To provide the ground truth of the study, three radiologists performed volumetric segmentation of the pancreas using the Nvidia organ segmentation mode on version 4.11 of the 3D Slicer software.

Radiologist segmentations (b, e) vs automated pancreatic segmentation predicted by model (e, f). Orange arrows indicate a slight relative over-segmentation of peripancreatic fat (c) and duodenum (f). Tumor areas are highlighted with a yellow overlay (b, e). The original cropped versions of the CT image are also provided for reference (a, c). Images and caption courtesy of Panagiotis Korfiatis, PhD.

Performance of the deep learning algorithm for pancreas segmentation
Internal test set NIH Pancreas-CT Dataset (Normal Cases) Decathlon Medical Segmentation dataset (cancer cases)
Average coefficient of similarity of the dice 0.892 0.855 0.865

The segmentation performance of the model did not differ significantly between cases of normal ductal adenocarcinoma and pancreatic ductal adenocarcinoma, Korfiatis said.

“Our analyzes also revealed that ground truth segmentations in the NIH-PCT dataset tended to miss minor parts of the pancreas in some cases, which were in fact included in the segmentations predicted by the model,” a- he declared.

In addition, the Dice similarity coefficient produced by the algorithm in cancer cases is similar to the level of interobserver variability – Dice similarity coefficient of 0.85 – shown in a previous study, according to Korfiatis.

He noted that automated segmentation errors were commonly seen at the interface of the pancreatic head and duodenum, as well as the pancreatic tail.

“These regions of the pancreas are very difficult to demarcate in some cases, even for an expert radiologist, and this further contributes to the greater intra-reader and inter-reader variability that can be observed for this task,” Korfiatis said.

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UT Arlington A National Success Model for Transfer Students https://music-massage.com/ut-arlington-a-national-success-model-for-transfer-students/ https://music-massage.com/ut-arlington-a-national-success-model-for-transfer-students/#respond Sun, 06 Jun 2021 10:59:51 +0000 https://music-massage.com/ut-arlington-a-national-success-model-for-transfer-students/ 04 June 2021 After collaborating on a national task force to reduce barriers for transfer students, the University of Texas at Arlington is leading an effort in the Dallas-Fort Worth Metroplex to implement some of its best practices and recommendations. Troy Johnson, vice president of enrollment management at UTA, was an ex-officio member of the […]]]>

04 June 2021

After collaborating on a national task force to reduce barriers for transfer students, the University of Texas at Arlington is leading an effort in the Dallas-Fort Worth Metroplex to implement some of its best practices and recommendations.

Troy Johnson, vice president of enrollment management at UTA, was an ex-officio member of the American Council on Education (ACE) national task force, which examined how to modify existing transfer and d ‘credit allocation to boost student success and reduce the cost and time to graduate.

“We are working together to remove barriers to national and local transfer for the benefit of students to go to college and stay in college,” Johnson said. “Ultimately, this will have a positive impact on the lives and families of UTA students.”

The task force made six recommendations in its report “Reimagining Transfer for Student Success: The National Task Force on the Transfer and Award of Credit”:

Prioritize the allocation of transfer credits and credits for prior learning and its application to degree requirements.

Adjust policies to improve students’ ability to receive credit for learning already acquired, including removing barriers that prevent students from accessing their transcripts to continue their studies at another institution.

Take advantage of innovative technologies to facilitate credit review, to ensure greater consistency in credit allocation determinations, and to increase process efficiency and speed.
Improve transparency by making it clear up front what credits will be awarded and how they will be applied to a degree path.

Dedicate resources to ensure quality counseling that provides students with early, knowledgeable and personalized information and advice.

Work with institutions to implement articulation agreements and structured pathways to increase transfer and credit allocation towards degree requirements.

“The global health crisis and the resulting economic fallout have widened equity gaps and threatened the gains of two decades of access to higher education for first-generation students, low-income students and college students. colored, ”said ACE President Ted Mitchell. “Improving credit transfer and allocation practices will not solve all of these unprecedented challenges, but it is a necessary and essential element in supporting student success in the future.”

Johnson is working to replicate the task force’s national pilot study in the North Texas region. Dallas College, the region’s largest community college district, is working with four of its top transfer universities to review transcripts for transfer students at UTA, Texas Woman’s University, Texas A&M University in Commerce and the University of North Texas at Dallas.

UT Arlington is the first in Texas and fifth nationally among the universities that enroll the most transfer students and recently earned a place on the 2021 Transfer Honor Roll of the Phi Theta Kappa Honor Society, the only University of Dallas-Fort Worth to do so.

Johnson has extensive experience serving in higher education, including serving as a rules negotiator for the United States Department of Education’s Discretionary Grants program, on the Texas STAAR Performance Descriptors Advisory Committee. Education Association and as chairman of the Council of Presidents and Chancellor’s Enrollment Service Efficiency Commission.

He said he was eager to implement these best practices among UT Arlington and some of its major transfer partners, including Dallas College and Tarrant County College.

“No matter the circumstances and even with the unprecedented stress that the COVID-19 pandemic has added, the UTA is here to serve students and their families,” Johnson said. “We will continue to lay the foundation for improved credit transfer policies and increase the opportunities for students to succeed in the 21st century.


This press release was produced by the City of Arlington. The opinions expressed here are those of the author.

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NBA 2021 playoffs: Nets vs Bucks odds, line, pick, model’s match 1 predictions on roll 100-66 https://music-massage.com/nba-2021-playoffs-nets-vs-bucks-odds-line-pick-models-match-1-predictions-on-roll-100-66/ https://music-massage.com/nba-2021-playoffs-nets-vs-bucks-odds-line-pick-models-match-1-predictions-on-roll-100-66/#respond Sat, 05 Jun 2021 17:14:17 +0000 https://music-massage.com/nba-2021-playoffs-nets-vs-bucks-odds-line-pick-models-match-1-predictions-on-roll-100-66/ The Eastern Conference semifinals between the Milwaukee Bucks and Brooklyn Nets should be a high profile affair as the teams rank first and second in points per game, respectively. Game 1 of this 2021 NBA Playoffs series takes place on Saturday night in Brooklyn, where the Nets defeated Milwaukee in a January game. The Bucks, […]]]>

The Eastern Conference semifinals between the Milwaukee Bucks and Brooklyn Nets should be a high profile affair as the teams rank first and second in points per game, respectively. Game 1 of this 2021 NBA Playoffs series takes place on Saturday night in Brooklyn, where the Nets defeated Milwaukee in a January game. The Bucks, however, have won both regular season competitions that took place in their arena. It will be the fourth all-time playoff meeting between these teams, with the Bucks winning the first two (1984, 1986) and the Nets winning in 2003.

Game 1 is scheduled to begin at 7:30 p.m. ET at the Barclays Center, which is expected to have around 15,000 fans. Latest Nets vs. Bucks from William Hill Sportsbook rank Milwaukee as a four-point favorite, down half a point from the opening line. The over-under for the total expected points is set at 239.5. Before you make Bucks vs. Nets, be sure to check out NBA predictions and betting tips from SportsLine’s proven computer model.

The SportsLine projection model simulates every NBA game 10,000 times and has grossed over $ 9,100 in profit on its top-rated NBA picks over the past two and more seasons. The model is up nearly $ 900 on her top-rated picks this season and entered the second full week of the 2021 NBA playoffs on a stunning roll of 100-66 on top-rated NBA picks by compared to the gap dating back to last season. Everyone who followed him saw huge returns.

Now the model has set her sights on Nets vs. Bucks in the 2021 NBA Playoffs. You can head over to SportsLine to see her picks. Here are several NBA betting lines for Bucks vs. Nets:

  • Bucks vs. Nets spread: Nets -4
  • Bucks vs Nets over-under: 239.5 points
  • Bucks vs Nets money line: Nets -175, Bucks +155
  • MIL: Bucks are 4-5-1 ATS in last 10 games
  • BKN: Nets are 8-1-1 ATS in last 10 games

Featured Game | Brooklyn Nets vs. Milwaukee Bucks

Why Bucks Can Cover

Milwaukee dominated their first-round streak as the Bucks not only avenged their playoff exit against the Miami Heat last year, but they also hosted the only sweep of those playoffs so far. Reigning two-time MVP Giannis Antetokounmpo is the catalyst for Milwaukee’s offense, but he’s got more help than ever this year. Khris Middleton is averaging 21.5 points per game with 49.2% shots and he showed he had the clutch gene by knocking down the winner of the game against Miami in Game 1. Newcomer Jrue Holiday was the two-way street that Milwaukee lacked in the lead, and he ranks in the top five in the playoffs in assists (9.8) and steals (2.3).

Even though Milwaukee will be without Donte DiVincenzo (ankle), he has incredible depth in every position. The Bucks averaged 10 players at least 15 minutes per game in the regular season, including playoff-tested PJ Tucker on the wing. Bryn Forbes and Bobby Portis both come off the bench with double-digit averages, and Milwaukee’s reserves have a clear advantage over the heaviest Nets.

Why the Nets can cover

Brooklyn has set the bar very high offensively this season, leading the NBA in offensive efficiency with over 1.17 points per possession. In the playoffs, the Nets were even better, crossing the Celtics scoring 1.28 points per possession in the first round. That included 2.11 assists for every turnover, an elite ratio, and the Nets even grabbed 30.1% of their own misfires on the offensive glass.

Brooklyn’s shooting prowess is elite, as Kevin Durant, James Harden and Kyrie Irving have combined for the key No.1 team in first-round and regular-season shooting efficiency. The Nets also have a path to efficient, switchable defense as they are above average at preventing free throw attempts and a top 10 team slowing down the effectiveness of opposing shots this season.

How to Make Bucks vs Nets Choices

SportsLine’s model looks at the total, projecting 231 combined points. The model also says that one side of the gap has all the value. You can only see the choice on SportsLine.

So who wins Bucks vs. Nets? And which side of the spread has all the value? Visit SportsLine now to find out which side of the spread you need to jump to, all from the model who crushed his NBA picks.

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NBA 2021 playoffs: Mavericks vs Clippers odds, line, picks, model match 6 predictions on roll 100-66 https://music-massage.com/nba-2021-playoffs-mavericks-vs-clippers-odds-line-picks-model-match-6-predictions-on-roll-100-66/ https://music-massage.com/nba-2021-playoffs-mavericks-vs-clippers-odds-line-picks-model-match-6-predictions-on-roll-100-66/#respond Fri, 04 Jun 2021 22:22:38 +0000 https://music-massage.com/nba-2021-playoffs-mavericks-vs-clippers-odds-line-picks-model-match-6-predictions-on-roll-100-66/ The Dallas Mavericks are aiming to advance to the Western Conference semifinals with a win Friday night. The Mavericks host the Los Angeles Clippers for Game 6 of a 2021 NBA playoff series in the first round, with the road team winning each of the first five contests. Luka Doncic (cervical) and Maxi Kleber (Achilles) […]]]>

The Dallas Mavericks are aiming to advance to the Western Conference semifinals with a win Friday night. The Mavericks host the Los Angeles Clippers for Game 6 of a 2021 NBA playoff series in the first round, with the road team winning each of the first five contests. Luka Doncic (cervical) and Maxi Kleber (Achilles) are listed as probable for the Mavericks. Serge Ibaka (back) is listed as skeptical for the Clippers.

Kick-off is 9 p.m. ET in Dallas. The latest Clippers vs Mavericks odds list Los Angeles as a 2.5-point favorite, while the under-total for points is set at 216.5. Before finalizing the Mavericks vs Clippers picks, be sure to check out the NBA predictions and betting tips from SportsLine’s proven computer model.

The SportsLine projection model simulates every NBA game 10,000 times and has grossed over $ 9,100 in profit on its top-rated NBA picks over the past two and more seasons. The model is up nearly $ 900 on her top-rated picks this season and entered the second full week of the 2021 NBA playoffs on a stunning roll of 100-66 on top-rated NBA picks by compared to the gap dating back to last season. Everyone who followed him saw huge returns.

Now the model has set her sights on Clippers vs. Mavericks in the 2021 NBA Playoffs. You can head over to SportsLine to see her picks. Here are several NBA betting lines for Mavericks vs Clippers:

  • Clippers vs. Mavericks spread: Clippers -2.5
  • Clippers vs Mavericks over-under: 216.5 points
  • Clippers silver line vs Mavericks: Clippers -140, Mavericks +120
  • LAC: Clippers are 4-6 ATS in last 10 games
  • DAL: Mavericks are 5-5 ATS in last 10 games

Featured Game | Dallas Mavericks vs. Los Angeles Clippers

Why the Clippers can cover

While the dynamics of a playoff series are always intriguing, the Clippers have the highest winning base in a larger sample. Los Angeles was the NBA’s No.3 offense this season, and with a notable difference from Dallas, the Clippers were also in the top eight defensive teams. Tyronn Lue’s side scored nearly 1.17 points per possession during the regular season, leading the NBA in 3-pointers (41.1%) and free throws (83.9%).

The Clippers trailed only the Brooklyn Nets in overall shooting efficiency, with above-average scores in offensive rebound rate (27.0%) and turnovers (13.2 per game). Los Angeles have an intriguing defensive approach with the ability to swing effectively, and the Clippers have limited their opponents to just 35.6% on a 3-point range this season. The Clippers were also in the top five in terms of defensive rebound rate (75.4%) and assists allowed (22.9 per game), with an above-average rating to limit opponents on the line. free throws.

Why Mavericks Can Cover

Dallas is marked by the singular talent of Doncic. The third-year creator is averaging 35.0 points, 9.4 assists and 8.0 rebounds per game in the series, and Doncic produced 44 points and 14 assists in a memorable Game 5 victory. He’s flanked by a strong supporting cast, with Tim Hardaway Jr. on the outside and Kristaps Porzingis near the edge, and the Mavericks are a great offensive team.

Dallas has scored nearly 1.15 points per possession in the regular season, and the Mavericks are over 1.16 points per possession in this series. The Mavericks have a strong offensive rebound rate of 28.5% against the Clippers, and they commit turnover on just 11.1% of possessions, an elite measure. Defensively, Dallas have a tough clash against the mighty Clippers, but they limited Los Angeles to just 100 points in Game 5 and the Mavericks were No. 2 in the NBA in assists allowed this season, earning just 22.7. cents per game.

How to make Clippers vs Mavericks picks

SportsLine’s model looks at the total, projecting 220 combined points. The model also indicates that one side of the gap reaches more than 50% of the time. You can only see the choice on SportsLine.

So who wins Clippers vs. Mavericks? And which side of the gap reaches well over 50% of the time? Visit SportsLine now to find out which side of the spread you need to jump to, all from the model who crushed his NBA picks.

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